Custom Peptides
Cayman Chemical Elafbrnor 10mg
An agonist of PPARα and PPARδ; increases HDL secretion and expression of lipid-related genes ABCA1, PLIN-2, and ABHD5 in Caco-2/TC7 cells in a PPARα-dependent manner; decreases levels of plasma triglycerides and total cholesterol while increasing plasma HDL and expression of Acox1 in the liver of ApoE2-KI wild-type, but not PPARα knockout, mice fed a Western diet when administered at a dose of 10 mg/kg; reduces diet-induced macro- and micro-steatosis in a PPARα-deficient mouse model of non-alcoholic steatohepatitis; reduces cholesterol and triglyceride accumulation as well as macrovesicular steatosis in the liver of insulin-resistant db/db mice fed the MCD diet
Cayman Chemical SURVODUTIDE 10MG
A dual peptide agonist of GLP-1R and GCGR; increases cAMP accumulation in CHO-K1 cells expressing GLP-1R or GCGR in reporter assays (EC50s = 0.33 and 0.52 nM, respectively); potentiates glucose-induced insulin secretion in isolated mouse, rat, and perifused human pancreatic islets; reduces body weight and food intake in diet-induced obese mice at 3 and 30 nmol/kg per day; reduces the levels of hepatic triglycerides and cholesterol, as well as plasma levels of glucagon, cholesterol, triglycerides, ALT, AST, insulin, and leptin in diet-induced obese mice; increases energy expenditure in diet-induced obese mice at 10 nmol/kg per day
Cayman Chemical 1DocosahexaenoylracglycRo 10mg
A monoacylglycerol; reduces ET-1-induced smooth muscle tension in isolated HPAs at 1-30 µM; reduces ET-1-induced increases in HPA cell proliferation and VEGF levels
Cayman Chemical Clevdpn 10mg
An inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes); preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively); decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats (ED30s = 316 and 58 nmol/kg, respectively)
Cayman Chemical Plumula nlumbns nfern 10mg
An alkaloid with diverse biological activities; inhibits ADP-, collagen-, thrombin-, U46619-, or adrenaline-induced aggregation of isolated human platelets at 3 µM; prevents LPS- and ATP-induced pyroptosis, NLRP3 inflammasome activation, and the production of ROS in HUVECs at 2 µM; decreases expression of the genes encoding PPARγ, C/EBPα, SREBP-1c, and FASN and reduces lipid accumulation in 3T3-L1 cells; enhances TRAIL-induced LC3-II accumulation and cell death in DU145 prostate cancer cells; improves reference and working memory, as well as reduces hippocampal lipid peroxidation and IL-6, IL-1β, and TNF-α levels, in a rat model of aluminum chloride-induced Alzheimer’s disease at 25 and 50 mg/kg
Cayman Chemical S-2238hydrochlorIde 10mg
A chromogenic substrate for thrombin; enzymatic cleavage releases pNA which can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity
Cayman Chemical 1Stearoyl2Lauroylracglyc 10mg
A diacylglycerol; contains stearic acid at the sn-1 position and lauric acid at the sn-2 position; a substrate for the rat diacylglycerol lipase DDHD2
Cayman Chemical Monascus nkaflavIn 10mg
A microbial metabolite with diverse biological activities; induces cytotoxicity in HepG2 and A549 cancer cells (IC50 = ~15 UG/ml for both); induces cell cycle arrest at the G0 phase in HepG2 cells at 15 UG/ml; reduces NO production in LPS-stimulated RAW 264.7 macrophages at 5, 10, and 15 UG/ml; increases lipolysis activity in IBMX-, dexamethasone-, and insulin-matured 3T3-L1 adipocytes at 10 µM; reduces blood glucose and serum insulin levels in mice fed a high-fat diet at 5 mg/kg per day
Cayman Chemical ADBPINCA pentnoIc ACD met 10mg
An expected compound produced by phase I metabolism of ADB-PINACA in vivo, based on the metabolism of comparable alkylindole CBs
Cayman Chemical Ophopogons radx Ruscogen 10mg
A steroid sapogenin with diverse biological activities; reduces PMA-induced adhesion of HL-60 cells to ECV304 cells (IC50 = 7.76 nM); decreases zymosan A-induced peritoneal leukocyte migration in rats at 5 mg/kg; inhibits ADP-induced platelet aggregation in rats at 12.5 mg/kg; prevents monocrotaline-induced increases in MAP, expression of IL-1β and TNF in plasma and lung, and endothelial cell apoptosis in pulmonary arterioles in a rat model of pulmonary hypertension; reduces proteinuria and renal macrophage infiltration in a rat model of streptozotocin-induced diabetes; decreases gene expression of inflammatory cytokines, dyslipidemia, and liver steatosis in a hamster model of high-fat diet-induced NASH
Cayman Chemical 7-APBhydrochlorIde 10mg
An analytical reference standard categorized as a benzofuran; a potential metabolite of 7-MAPB based on the published metabolism of 5-MAPB; intended for research and forensic applications
Cayman Chemical IsoursodeoxycholIc AcId 10mg
An epimer of ursodeoxycholic acid; decreases serum ALP, AST, and ALT levels in bile duct-ligated rats at 2,500 mg/kg in the diet
Cayman Chemical NKH477hydrochlorIde 10mg
A water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously; stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms; relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM